3-(4'-Bromo[1,1'-biphenyl]-4-yl)-1,2,3,4-tetrahydro-1-naphthalenol
3-(4'-Bromo[1,1'-biphenyl]-4-yl)-1,2,3,4-tetrahydro-1-naphthalenol
CAS: 56181-82-9
Molecular Formula: C22H19BrO
3-(4'-Bromo[1,1'-biphenyl]-4-yl)-1,2,3,4-tetrahydro-1-naphthalenol - Names and Identifiers
| Name | 3-(4'-Bromo[1,1'-biphenyl]-4-yl)-1,2,3,4-tetrahydro-1-naphthalenol |
| Synonyms | 3-(4'-Bromo-4-biphenyl-4-yl)-1,2,3,4-tetenol 3-(4′-brome-4-biphenyl-4-yl)-1,2,3,4-tetrahydro-1-naphthanol 3-[4-(4-broMophenyl)phenyl]-1,2,3,4-tetrahydronaphthalen-1-ol 3-(4'-bromo[1,1'-biphenyl]-4-yl)-1,2,3,4-tetrahydro-1-naphthol 3-(4'-Bromo[1,1'-biphenyl]-4-yl)-1,2,3,4-tetrahydro-1-naphthalenol 1-Naphthalenol, 3-(4'-bromo(1,1'-biphenyl)-4-yl)-1,2,3,4-tetrahydro- 3-(4''-BROMO[1,1''-BIPHENYL]-4-YL)-1,2,3,4-TETRAHYDRO-1-NAPHTHALENOL |
| CAS | 56181-82-9 |
| EINECS | 260-038-0 |
3-(4'-Bromo[1,1'-biphenyl]-4-yl)-1,2,3,4-tetrahydro-1-naphthalenol - Physico-chemical Properties
| Molecular Formula | C22H19BrO |
| Molar Mass | 379.29 |
| Density | 1.359±0.06 g/cm3(Predicted) |
| Boling Point | 512.8±50.0 °C(Predicted) |
| pKa | 14.15±0.40(Predicted) |
| Storage Condition | 2-8℃ |
| Physical and Chemical Properties | Chemical quality This product is white crystal, m.p.145 ~ 147 ℃, insoluble in water, soluble in dichloroethane, acetic acid and other solvents. |
| Use | Use 3-(4 '-bromo-4-biphenyl)-1,2,3, 4-tetrahydro-1-naphthol is an intermediate of the rodenticides bromneol and thiabradine. |
3-(4'-Bromo[1,1'-biphenyl]-4-yl)-1,2,3,4-tetrahydro-1-naphthalenol - Upstream Downstream Industry
| Raw Materials | Sodium hydride Polyphosphoric acid Potassium borohydride Biphenyl beta-Tetralone ETHYLMALONIC ACID 2-Bromoethylbenzene |
3-(4'-Bromo[1,1'-biphenyl]-4-yl)-1,2,3,4-tetrahydro-1-naphthalenol - Nature
| EPA chemical information | 1-Naphthalenol, 3-(4'-bromo[1,1'-biphenyl]-4-yl)-1,2,3,4-tetrahydro- (56181-82-9) |
Last Update：2024-04-10 22:29:15
3-(4'-Bromo[1,1'-biphenyl]-4-yl)-1,2,3,4-tetrahydro-1-naphthalenol - Production method
its preparation method is 2-(4 & prime;-bromo -4-biphenyl)-2-bromoethylbenzene and diethyl malonate are added with sodium hydride into DMF solvent, heated to 90 ℃ for 6 hours, cooled and poured into water, precipitated solids, filtered, refluxed with potassium hydroxide ethanol solution for 6 hours, added with water for acidification, and filtered to obtain 2-[2-(4 & prime;-Bromo-4-biphenyl) phenylethyl] malonic acid.
The above-mentioned malonic acid derivative and polyphosphoric acid are added to the reaction bottle, reacted at 160~170 ℃ for 2h, cooled and added toluene, washed with water, and removed toluene to obtain 3-(4-bromo-4-biphenyl) tetrahydronaphthone, the naphthone is reduced with potassium borohydride in anhydrous ethanol, the reaction temperature is 81 ℃, reflux is 3h, cooled and poured into water.
Last Update：2024-04-10 22:29:15
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Product Name: 3-(4'-Bromo[1,1'-biphenyl]-4-yl)-1,2,3,4-tetrahydro-1-naphthalenol Visit Supplier Webpage Request for quotation
CAS: 56181-82-9
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CAS: 56181-82-9
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Raw Materials for 3-(4'-Bromo[1,1'-biphenyl]-4-yl)-1,2,3,4-tetrahydro-1-naphthalenol